一、口腔组织工程技术的基础研究与临床转化研究方向:
1. ShanZhang, B Ma,S Wang, J Duan, J Qiu,Shaohua Ge. Mass-production of fluorescent chitosan/graphene oxide hybridmicrospheres for in vitro 3D expansion of human umbilical cord mesenchymal stemcells. Chemical Engineering Journal, 2018, 331: 675-684. IF=6.735
2. Ma B, Han J, Zhang S, Liu F, Wang S, Duan J, Sang Y, Jiang H, Li D, Ge S, Liu H.Hydroxyapatite nanobelt/polylactic acid Janus membrane withosteoinduction/barrier dual functions for precise bone defect repair. Actabiomaterialia, 2018, 71: 108-117. IF=6.383
3. Shang L, Wang T, Tong D, Kang W, Liang Q, Ge S.Prolyl hydroxylases positively regulated LPS‐induced inflammation in humangingival fibroblasts via TLR4/MyD88‐mediated AKT/NF‐κB and MAPK pathways. Cellproliferation, 2018: e12516. IF=4.936
4. Yue S, Wu J, Zhang Q, Zhang K, Weir MD, Imazato S, Bai Y, Xu HHK.Novel dental adhesive resin with crack self-healing, antimicrobial andremineralization properties. Journal of dentistry, 2018. IF=3.77
5. Li NB, Sun SJ, Bai HY, Xiao GY, Xu WH, Zhao JH, Chen X, Lu YP, Zhang YL. Preparation ofwell-distributed titania nanopillar arrays on Ti6Al4V surface by inductionheating for enhancing osteogenic differentiation of stem cells. Nanotechnology,2017, 29(4): 045101. IF=3.404
6. Kang W, Shang L, Wang T, Liu H, Ge S. Rho-kinaseregulates LPS-induced NF-κBactivation and inflammatory cytokines production through p38 MAPK pathway inhuman gingival fibroblasts.J Periodontol, 2018,89(7):883-893 IF=3.392
7. ZhangY, Xing Y, Jia L. An in vitro comparative study of multi-sources derived mesenchymalstem cells for bone tissue engineering. Stem cells and development, 2018 (ja).IF=3.315
8. Han J, Ma B, Liu H, Wang T, Wang F, Xie C, Li M, Liu H, Ge S.Hydroxyapatite nanowires modified polylactic acid membrane playsbarrier/osteoinduction dual roles and promotes bone regeneration in a ratmandible defect model. Journal of Biomedical Materials Research Part A, 2018.IF=3.231
9. Zheng M, Liu X, Zhou Q, Liu G.HOTAIRM 1 competed endogenously with miR-148a to regulate DLGAP 1 in head andneck tumor cells. Cancer medicine, 2018. IF=3.202
10. Jia T, Wang YN, Zhang D, Xu X.1α, 25-dihydroxyvitamin D3 promotes osseointegration of titanium implant viadownregulating AGEs/RAGE pathway in T2DM. Endocrine Connections, 2018, 1(aop).IF=3.041
11. Ji Y, Jia L, Zhang Y, Xing Y, Wu X, Zhao B, Zhang D, Xu X, Qiao X. Antitumor activity ofthe plant extract morin in tongue squamous cell carcinoma cells. Oncologyreports, 2018, 40(5): 3024-3032. IF=2.976
12. Zhou R, Shen L, Yang C, Wang L, Guo H, Yang P, Song A. Periodontitis MayRestrain the Mandibular Bone Healing via Disturbing Osteogenic and OsteoclasticBalance. Inflammation, 2018: 1-12. IF=2.884
13. Li A, Gu K, Wang Q, Chen X, Fu X, Wang Y, Wen Y. Epigallocatechin-3-gallateaffects the proliferation, apoptosis, migration and invasion of tongue squamouscell carcinoma through the hippo-TAZ signaling pathway. International journalof molecular medicine, 2018, 42(5): 2615-2627. IF=2.784
14. Ji Y, Zhang P, Xing Y, Jia L, Zhang Y, Jia T, Wu X, Zhao B, Xu X. Effect of 1α,25-dihydroxyvitamin D3 on the osteogenic differentiation of human periodontalligament stem cells and the underlying regulatory mechanism. Internationaljournal of molecular medicine, 2018. IF=2.784
15. Zhang W, Wang S, Ge S, Chen J, Ji P. The relationshipbetween substrate morphology and biological performances of nano-silver-loadeddopamine coatings on titanium surfaces. Royal Society open science, 2018, 5(4):172310. IF=2.504
16. Sun S, Zhang Y, Zeng D, Zhang S, Zhang F, Yu W. PLGA film/Titaniumnanotubues as a sustained growth factor releasing system for dental implants.Journal of Materials Science: Materials in Medicine, 2018, 29(9): 141. IF=2.448
17. Sun B, Wen Y, Wu X, Zhang Y, Qiao X, Xu X. Expression pattern ofYAP and TAZ during orthodontic tooth movement in rats. Journal of molecularhistology, 2018, 49(2): 123-131. IF=2.412
18. Jia L, Gu W, Zhang Y, Jiang B, Qiao X, Wen Y. ActivatedYes-Associated Protein Accelerates Cell Cycle, Inhibits Apoptosis, and DelaysSenescence in Human Periodontal Ligament Stem Cells. International journal ofmedical sciences, 2018, 15(11): 1241. IF=2.284
19. Du J, Hu W, Yang C, Wang Y, Wang X, Yang P. C-reactive protein isassociated with the development of tongue squamous cell carcinoma. Actabiochimica et biophysica Sinica, 2018, 50(3): 238-245. IF=2.224
20. Lin X, Xie J, Sun S, Ren X, Kong J, Ji P. Toll-Like Receptor 4(TLR4) Stimulates Synovial Injury of Temporomandibular Joint in Rats Throughthe Activation of p38 Mitogen-Activated Protein Kinase (MAPK) SignalingPathway[J]. Medical science monitor: international medical journal ofexperimental and clinical research, 2018, 24: 4405. IF=1.894
21. Chen H, Li Y, Reiber JH, de Lange J, Tu S, van der Stelt P, Lobbezoo F, Aarab G. Analyses ofaerodynamic characteristics of the oropharynx applying CBCT: obstructive sleepapnea patients versus control subjects. Dentomaxillofacial Radiology, 2018,47(2): 20170238. IF=1.848
22. ChenH, Aarab G, de Lange J. The effects of non-continuous positive airway pressure(non-CPAP) therapies on the aerodynamic characteristics of the upper airway ofobstructive sleep apnea patients: a systematic review. Journal of Oral andMaxillofacial Surgery, 2018. IF=1.799
23. NiuW, Wang P, Ge S, Ji P. Effects of Platelet Concentrates Used inAlveolar Ridge Preservation: A Systematic Review. Implant dentistry,2018, 27(4): 498-506. IF=1.110
24. GaoY, Wang Z, Qiao X. Relationship between Moderate-Severe Periodontitis andIschemic Stroke. NeuroQuantology, 2018, 16(6). IF=0.453
二、口腔组织工程宿主因素研究及安全性评价研究方向:
1. Pan Y, Song J, Ma L, Zong X, Chen H, Zhao B, Yu Q, Song H.Carbon Monoxide Releasing Molecule 3 Inhibits Osteoclastogenic Differentiationof RAW264.7 Cells by Heme Oxygenase-1. Cellular Physiology and Biochemistry, 2018,50(5): 1988-2003. IF=5.50
2. Zhang S, Liu Y, Zheng Z, Zeng X, Liu D, Wang C, Ting K.MicroRNA-223 Suppresses Osteoblast Differentiation by Inhibiting DHRS3.Cellular Physiology and Biochemistry, 2018, 47(2): 667-679. IF=5.50
3. Liu X, Li Q, Huang P,Zhang F. EGFR-mediated signaling pathway influences the sensitivity of oralsquamous cell carcinoma to JQ1. Journal of Cellular Biochemistry, 2018.IF=2.959
4. Yu X, Liu S, Wang W,Shu LI. Periodontal ligament‑associated protein‑1 delays rat periodontal bonedefect repair by regulating osteogenic differentiation of bone marrow stromalcells and osteoclast activation. International journal of molecular medicine,2018, 41(2): 1110-1118. IF=2.784
5. Li J, Song L, Hou M,Hui S. Carbon monoxide releasing molecule‑3 promotes the osteogenic differentiationof rat bone marrow mesenchymal stem cells by releasing carbon monoxide.International journal of molecular medicine, 2018, 41(4): 2297-2305. IF=2.784
6. Liu X, Qiao B, Zhao T, Hu F, Lam AK, Tao Q.Sox2 promotes tumor aggressiveness and epithelial‑mesenchymal transition intongue squamous cell carcinoma. International journal of molecular medicine,2018, 42(3): 1418-1426. IF=2.784
7. Zhou J, Gao X, Huang S, Ma L, Cui Y, Wang H, Qiu J, Wang L, Dong Q, Chen Z, Wang X, Zhang D.Simvastatin Improves the Jaw Bone Microstructural Defect Induced by HighCholesterol Diet in Rats by Regulating Autophagic Flux. BioMed researchinternational, 2018, 2018. IF=2.583
8. Yu X, Liu S, Chen H, Zhao X, Chen X, Du Y, Li S.CGRP gene-modified rBMSCs show better osteogenic differentiation capacity invitro. Journal of molecular histology, 2018: 1-11. IF=2.412
9. Liu X, Wu H, Huang P.Zhang FJQ 1 and PI 3K inhibition synergistically reduce salivary adenoid cysticcarcinoma malignancy by targeting the c-Myc and EGFR signaling pathways.Journal of Oral Pathology & Medicine, 2018. IF=2.237
10. Wang X, Liu W, Wang P, Li S.RNA interference of long noncoding RNA HOTAIR suppresses autophagy and promotesapoptosis and sensitivity to cisplatin in oral squamous cell carcinoma. Journalof Oral Pathology & Medicine, 2018. IF=2.237
11. Liu S, You Z, Ma C, Wang Y, Zhao H.Effectiveness of drainage in mandibular third molar surgery: a systematicreview and meta-analysis. Journal of Oral and Maxillofacial Surgery, 2018. IF=1.779
12. Zhang A, Tang H, Liu S, Ma C, Ma S, Zhao H.Anesthetic efficiency of articaine versus lidocaine in the extraction of lower thirdmolar: A meta-analysis and systematic review. Journal of Oral and MaxillofacialSurgery, 2018. IF=1.779
13. Liu Y, Song J, Zhang J, Yang L, Liu Z, Wang X.BTB/POZ domain-containing protein 7 is inversely associated with fibronectinexpression in salivary adenoid cystic carcinoma. Oral surgery, oral medicine,oral pathology and oral radiology, 2018, 125(5): 468-477. IF=1.718
14. Xiao CJ, Yu XJ, Xie JL, Liu S, Li S.Protective effect and related mechanisms of curcumin in rat experimentalperiodontitis. Head & face medicine, 2018, 14(1): 12. IF=1.606
15. Su Z, Zhang J, Gao P, Shi J, Qi M, Chen L, Wang X.Synovial sarcoma of the tongue: report of a case and review of the literature.The Annals of The Royal College of Surgeons of England, 2018, 100(5):e118-e122. IF=1.47
16. BaoQ, Zhang J, Wang X X. Effects of Btbd7 knockdown on the proliferation of humandental pulp cells and expression of Dspp. International journal of clinical andexperiemental pathology, 2018, 11(3): 1460-1465. IF=1.396
17. Zhaobin, Liu tingting, Song hui. The Biological Effects of Low Intensity PulsedUltrasound in Osteoblasts.Transl Med (Sunnyvale), 2018, 8:1 IF=0.2
三、硬组织发生及相关疾病的机制研究方向:
1. He Q, Yang S, Gu X, Li M, Wang C, Wei F.Long noncoding RNA TUG1 facilitates osteogenic differentiation of periodontalligament stem cells via interacting with Lin28A. Cell death & disease,2018, 9(5): 455. IF=5.638
2. Liu Y, Zeng X, Miao J, Liu C, Wei F, Liu D, Zheng Z, Ting K, Wang C, Guo J.Upregulation of long noncoding RNA MEG3 inhibits the osteogenic differentiationof periodontal ligament cells. Journal of cellular physiology, 2018. IF=3.923
3. Zhang X, Feng H, Li Z, Guo J, Li M.Aspirin is Involved in the Cell Cycle Arrest, Apoptosis, Cell Migration, andInvasion of Oral Squamous Cell Carcinoma. International journal of molecularsciences, 2018, 19(7): 2029. IF=3.687
4. Zhang X, Feng H, Li D, Liu S, Amizuka N, Li M.Identification of Differentially Expressed Genes Induced by AberrantMethylation in Oral Squamous Cell Carcinomas Using Integrated BioinformaticAnalysis. International journal of molecular sciences, 2018, 19(6): 1698.IF=3.687
5. Han Y, Wang X, Ma D, Wu X, Yang P, Zhang J.Ipriflavone promotes proliferation and osteogenicdifferentiation of periodontal ligament cells by activating GPR30/PI3K/AKTsignaling pathway. Drug design, development and therapy, 2018, 12: 137.IF=2.987
6. Zhang X, Feng H, Du J, Sun J, Li D, Hasegawa T, Amizuka N, Li M.Aspirin promotes apoptosis and inhibits proliferation by blocking G0/G1 into Sphase in rheumatoid arthritis fibroblast-like synoviocytes via downregulationof JAK/STAT3 and NF-κB signaling pathway. Internationaljournal of molecular medicine, 2018, 42(6): 3135-3148. IF=2.784
7. Zhang X, Feng H, Li Z, Li D, Liu S, Huang H, Li M.application of weighted gene co-expression network analysis to identify keymodules and hub genes in oral squamous cell carcinoma tumorigenesis.OncoTargets and therapy, 2018, 11: 6001. IF=2.656
8. He D, An Y, Li Y, WangJ, Wu G, Chen L, Zhu G. RNA sequencing reveals target genes oftemporomandibular joint osteoarthritis in rats after the treatment oflow-intensity pulsed ultrasound. Gene. 2018 Sep 25;672:126-136. IF=2.498
9. An Y, Song Y, Wang Z,Wang J, Wu G, Zhu G, Chen L. Effect of low-intensity pulsed ultrasound on thebiological behaviors of bone marrow mesenchymal stem cells on titanium withdifferent surface topographies.Am J Transl Res.2018 Jan15;10(1):67-76. IF=2.201
10. LiuH, Li D, Zhang Y. Inflammation, mesenchymal stem cells and bone regeneration.Histochemistry and cell biology, 2018: 1-12. IF=2.164
11. Liu H, Li D, Liu S, Liu Z, Li M.Histochemical evidence of IGF2 mRNA-binding protein 2-mediated regulation ofosteoclast function and adhesive ability. Histochemistry and cell biology,2018, 149(4): 343-351. IF=2.164
12. Chen H, van EijnattenM, Aarab G, Forouzanfar T, de Lange J, van der SteltP, Lobbezoo F, Wolff J.Accuracy of MDCT and CBCT in three-dimensional evaluation of the oropharynxmorphology. European journal of orthodontics, 2017, 40(1): 58-64. IF=2.033
13. Ma D, Wang X, Guo J, Zhang J, Cai T.Identification of a novel mutation of RUNX2 in a family with supernumeraryteeth and craniofacial dysplasia by whole-exome sequencing: A case report andliterature review. Medicine, 2018, 97(32). IF=2.028
14. Liu B, Feng W, Hasegawa T, Amizuka N, Li M.Type 1 diabetes mellitus induced low bone turnover in ovariectomized rats.Histology and histopathology, 2018: 18024-18024. IF=2.015
15. WuX, Wang X, Ren X. Effects of psoralen, a traditionalChinese medicine, on relapse and bone remodeling after orthodontic toothmovement in rats. International journal of clinical and experimentalmeidicine, 2018, 11(4): 3587-3595. IF=1.070
四、皮肤组织工程研究方向:
1. Wu X, Tommasi diVignano A, Zhou Q, Michel-DziunyczPJ, Bai F, Mi J, Qin J1, Zu T, Hofbauer GFL.The ARE-binding protein Tristetraprolin (TTP) is a novel target and mediator ofcalcineurin tumor suppressing function in the skin. PLoS genetics, 2018, 14(5):e1007366. IF=5.54
2. Chang F, Zhang Y, Mi J, Zhou Q, Bai F, Xu X, Fisher DE, Sun Q, Wu X.ROCK inhibitor enhances the growth and migration of BRAF-mutant skin melanomacells. Cancer science, 2018, 109(11): 3428. IF=4.372
3. Wen J, Zu T, Zhou Q, Leng X, Wu X.Y-27632 simplifies the isolation procedure of human primary epidermal cells byselectively blocking focal adhesion of dermal cells. Journal of tissueengineering and regenerative medicine, 2018, 12(2): e1251-e1255. IF=4.089
4. Liu Z, Wen J, Leng X, Zhou Q, Zhou C, Zhao H, Wu X.A Simplified and Efficient Method to Isolate Primary Human Keratinocytes fromAdult Skin Tissue. JoVE (Journal of Visualized Experiments), 2018 (138):e57784-e57784. IF=1.184
5. Qian H, Leng X, Wen J, Zhou Q, Xu X, Wu X.One-Step Simple Isolation Method to Obtain Both Epidermal and Dermal Stem Cellsfrom Human Skin Specimen. Methods inMolecular Biology, 2018.25(3)pp1-10.